About this item
Mitochondrial NMNAT isoform
- UniProt link Q96T66: NMNAT3 (human)
Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. Can use tiazofurin monophosphate as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity, mitochondrial NMNAT isoform can use NAD(+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NAADP+. Protects against axonal degeneration following injury.
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Specifications
- Conjugation:Unconjugated
- Source:E. coli
- Species:Human
- Storage Conditions:−20 °C
- Form:Liquid
- Shipping Conditions:–20 °C, blue Ice
- Enzyme Name:NMNAT3
- Enzyme Activity:>2U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1µmol of NAD+ per min.
- Purity:95%
- Molecular Weight:~27 kDa (monomer)
- Concentration:1 mg/ml
- Formulation:In 50 mM TRIS-HCl, pH 8.0, containing 300 mM sodium chloride, 1 mM DTT and 10% glycerol.