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Specifications
- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:CHO cells
- Species:Human
- Size:100 µg
- Storage Conditions:–20 °C
- Endotoxin Content:<0.06EU/µg
- Gene ID:NP_079515.2
- Protein Synonyms:Programmed Cell Death 1 Ligand 2|PDL2|B7-DC|PDCD1 Ligand 2
- Protein/Peptide Name:CD273
- Purity:98%
- Endotoxin Level:Low
- Formulation:Lyophilized from 0.2µm-filtered solution in PBS.
- Shipping Temperature:-20 °C, Blue Ice
- Cat. No.:102981-502
- Supplier no.:HF210PDL2C100
Specifications
About this item
T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.