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Specifications
- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:CHO cells
- Species:Human
- Size:100 µg
- Storage Conditions:–20 °C
- Endotoxin Content:<0.06EU/µg
- Biological Activity:Measured by its binding ability in a functional ELISA.
- Gene ID:AAH06196.1
- Protein Synonyms:CD137 Antigen|Tumor Necrosis Factor Receptor Superfamily Member 9|T Cell Antigen ILA|TNFRSF9|MGC2172|ILA|CDw137|4-1BB|4-1BB Ligand Receptor T Cell|Antigen 4-1BB Homolog
- Protein/Peptide Name:CD137
- Purity:98%
- Endotoxin Level:Low
- Formulation:Lyophilized from 0.2µm-filtered solution in PBS.
- Shipping Temperature:-20 °C, Blue Ice
- Cat. No.:102981-484
- Supplier no.:HF210CD137C100
Specifications
About this item
Human CD137 (4-1BB) is a costimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor receptor-associated factors (TRAF), the adaptor protein and mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been shown to augment secondary CTL responses to several viruses and increase antitumor immunity. 4-1BB is therefore a promising candidate for immunotherapy of human cancer.