Recombinant Flagellin (from E. coli)
About this item
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) and the intracellular protein NLRC4 (NLR family CARD domain-containing protein 4).
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- Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
- Return Policy
Product Details & Documents
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) and the intracellular protein NLRC4 (NLR family CARD domain-containing protein 4).
Specifications for Product Family
Specifications
Specifications
- Catalog No:
- 102980-218
- 102980-220
- Protein/Peptide Name:
- Flagellin
- Flagellin
- Protein Synonyms:
- FliC
- FliC
- Protein/Peptide Type:
- Recombinant
- Recombinant
- Source:
- E. coli
- E. coli
- Conjugation:
- Unconjugated
- Unconjugated
- Gene ID:
- P06179
- P06179
- Endotoxin Level:
- Low
- Low
- Endotoxin Content:
- <0.01EU/µg
- <0.01EU/µg
- Biological Activity:
- Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, in vivo on expression of CCL20 or IL-6. TLR5 can be stimulated in vitro by Flagellin (rec.) at concentration range of 5-50ng/ml and in vivo at a starting concentration of 0.1-1µg/mouse. Inflammasome NLRC4 can be activated at a concentration range of 1-5µg/ml on bone-marrow macrophages in the presence of streptolysin O (SLO, 25µg/ml), a protein that allows delivery of exogenous molecules into the cytosol of living cells.
- Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, in vivo on expression of CCL20 or IL-6. TLR5 can be stimulated in vitro by Flagellin (rec.) at concentration range of 5-50ng/ml and in vivo at a starting concentration of 0.1-1µg/mouse. Inflammasome NLRC4 can be activated at a concentration range of 1-5µg/ml on bone-marrow macrophages in the presence of streptolysin O (SLO, 25µg/ml), a protein that allows delivery of exogenous molecules into the cytosol of living cells.
- Purity:
- 95%
- 95%
- Concentration:
- 0.1mg/ml after reconstitution.
- 0.1mg/ml after reconstitution.
- Formulation:
- Lyophilized. Contains PBS.
- Lyophilized. Contains PBS.
- Storage Conditions:
- –20 °C
- –20 °C
- Shipping Temperature:
- -20 °C, Blue Ice
- -20 °C, Blue Ice
Specifications
Product Family Options
Product Information
- SizeAvailabilityPrice
- Supplier Number: AG-40B-0125-C010Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:Marketsource
More
Specifications
Cat. No.102980-218Protein/Peptide NameFlagellinProtein SynonymsFliCProtein/Peptide TypeRecombinantSourceE. coliConjugationUnconjugatedGene IDP06179Endotoxin LevelLowEndotoxin Content<0.01EU/µgBiological ActivityActivation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, in vivo on expression of CCL20 or IL-6. TLR5 can be stimulated in vitro by Flagellin (rec.) at concentration range of 5-50ng/ml and in vivo at a starting concentration of 0.1-1µg/mouse. Inflammasome NLRC4 can be activated at a concentration range of 1-5µg/ml on bone-marrow macrophages in the presence of streptolysin O (SLO, 25µg/ml), a protein that allows delivery of exogenous molecules into the cytosol of living cells.Purity95%Concentration0.1mg/ml after reconstitution.FormulationLyophilized. Contains PBS.Storage Conditions–20 °CShipping Temperature-20 °C, Blue IceMarketsource - Supplier Number: AG-40B-0125-3010Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:Marketsource
More
Specifications
Cat. No.102980-220Protein/Peptide NameFlagellinProtein SynonymsFliCProtein/Peptide TypeRecombinantSourceE. coliConjugationUnconjugatedGene IDP06179Endotoxin LevelLowEndotoxin Content<0.01EU/µgBiological ActivityActivation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, in vivo on expression of CCL20 or IL-6. TLR5 can be stimulated in vitro by Flagellin (rec.) at concentration range of 5-50ng/ml and in vivo at a starting concentration of 0.1-1µg/mouse. Inflammasome NLRC4 can be activated at a concentration range of 1-5µg/ml on bone-marrow macrophages in the presence of streptolysin O (SLO, 25µg/ml), a protein that allows delivery of exogenous molecules into the cytosol of living cells.Purity95%Concentration0.1mg/ml after reconstitution.FormulationLyophilized. Contains PBS.Storage Conditions–20 °CShipping Temperature-20 °C, Blue IceMarketsource
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