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Specifications
- Conjugation:Unconjugated
- Protein Function:Interleukins
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Size:10 µg
- Storage Conditions:–20 °C
- Endotoxin Content:<0.01EU/µg
- Gene ID:Q9NZH7
- Amino Acid Number:5 to 157
- Protein Synonyms:IL-1F8|Interleukin-36beta Interleukin-1 Family Member 8
- Protein/Peptide Name:IL-36beta
- Purity:95%
- Molecular Weight:~15kDa (SDS-PAGE)
- Endotoxin Level:Low
- Concentration:0.1mg/ml after reconstitution.
- Formulation:Lyophilized. Contains PBS + 0.5% trehalose.
- Shipping Temperature:-20 °C, Blue Ice
- Cat. No.:102980-190
- Supplier no.:AG40B0117C010
Specifications
About this item
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.