About this item
IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
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Specifications
- Conjugation:Unconjugated
- Protein Function:Interleukins
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Mouse
- Storage Conditions:–20 °C
- Endotoxin Content:<0.05EU/µg
- Biological Activity:Inhibits the IL-6 induced expression of IL-36alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9) in BMDCs. 1µg/ml of IL-36Ra inhibits the activity of 10 ng to 100 ng/ml of the agonists.
- Gene ID:Q9QYY1
- Amino Acid Number:3 to 156
- Protein Synonyms:Interleukin-1 Homolog 3|IL-1delta|Interleukin-36 Receptor Antagonist Protein|Interleukin-1 Family Member 5|Interleukin-1-like Protein 1|Interleukin-1delta|IL-1F5
- Protein/Peptide Name:IL-36Ra
- Purity:95%
- Molecular Weight:~17kDa
- Endotoxin Level:Low
- Concentration:0.1mg/ml after reconstitution.
- Formulation:Lyophilized. Contains PBS.
- Shipping Temperature:-20 °C, Blue Ice