Specifications
- Antibody Type:Primary
- Antigen Name:Interleukin 38
- Antigen Symbol:IL-38
- Clonality:Monoclonal
- Clone:Nhat-1
- Conjugation:Unconjugated
- ELISA:Yes
- Isotype:IgG2b kappa
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:100 µg
- Form:liquid
- Antigen Synonyms:IL-1F10|Interleukin-1 Family Member 10|Interleukin-38
- Storage Temperature:–20 °C
- Concentration:1mg/ml
- Shipping Temperature:-20° C
- Immunogen:Recombinant human IL-38.
- Cat. No.:102971-630
- Supplier no.:AG20B0070C100
Specifications
About this item
IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.
Type: Primary
Antigen: IL-38
Clonality: Monoclonal
Clone: Nhat-1
Conjugation: Unconjugated
Epitope:
Host:
Isotype: Mouse IgG2bkappa.
Reactivity: Human, Mouse