To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:
- • State issued document with your organization's Federal Tax ID Number
- • State issued document with your organization's Resale Tax ID Number
- • City or County issued Business License
- • State Department of Health Services License
- • Any other ID issued by the State that includes the business name & address
* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. Avantor will not lift restrictions for residential shipping addresses.
Specifications
- Antibody Type:Primary
- Antigen Symbol:CASP4
- Clonality:Monoclonal
- Clone:Flamy-1
- Conjugation:Biotin
- ImmunoPrecipitation:Yes
- Isotype:IgG2b kappa
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:100 µg
- Form:liquid
- Gene ID:P70343
- Antigen Synonyms:Caspase-11 (mouse)|Protease ICH-2 (human)|Protease ICH-3 (mouse)|Caspase-4 (human)|ICE(rel)-II (human)|Protease TX (human)
- Storage Temperature:–20 °C
- Concentration:1mg/ml
- Shipping Temperature:-20° C
- Immunogen:Recombinant mouse Caspase-11 (aa 81-373).
- Cat. No.:102971-606
- Supplier no.:AG20B0060BC100
Specifications
About this item
Inflammatory caspases (also known as group I caspases) are encoded by three main genes in humans, caspase-1, caspase-4 and caspase-5 and three main genes in mouse, caspase-1, caspase-11 and caspase-12. Caspase-11 is the murine orthologue of human caspase-4 and -5. Murine caspase-11 is a poorly characterized member of the caspase-1 subfamily. Caspase-11-deficient embryonic fibroblasts are resistant to apoptosis induced by ectopic expression of caspase-1, suggesting that caspase-11 is an upstream activator of caspase-1. Unlike caspase-1, the expression of caspase-11 is LPS-inducible and it is reasonable to postulate that other members of the family are regulated at the transcriptional or translational level by extracellular stimuli. Recently caspase-11 has been shown to be required for activation of the Nlrp3 inflammasome upon E. coli, V. cholerae and C. rodentium infection. The upstream activators of caspase-11 are TLR4 and TRIF, that modulate enteropathogen-induced inflammasome activation by promoting caspase-11 expression and activation. Formation of ASC foci (specks), a measure of NLRP3/ASC complex formation, requires caspase-11 but not caspase-1 indicating that caspase-11 acts upstream of the NLRP3/ASC complex.
Type: Primary
Antigen: CASP4
Clonality: Monoclonal
Clone: Flamy-1
Conjugation: Biotin
Epitope:
Host:
Isotype: Mouse IgG2bkappa
Reactivity: Human, Mouse