Specifications
- Antibody Type:Primary
- Antigen Name:[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
- Antigen Symbol:PDP1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Reactivity:Human,Rat
- Western Blot:Yes
- Size:400 ul
- Epitope:Amino Acid Range = 308-336
- Form:Liquid
- Gene ID:Q9P0J1
- Antigen Synonyms:PDP1
- Modification:None
- Storage Buffer:Supplied in PBS with 0.09% (W/V) sodium azide.
- Molecular Weight:61 kDa
- Storage Temperature:Store at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:0.33 mg/mL
- Shipping Temperature:4 °C
- Immunogen:This PDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDP1.
- Purification:This antibody is purified through a protein A column, followed by peptide affinity purification.
- Cat. No.:76011-916
Specifications
About this item
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
For WB starting dilution is: 1:2000 For IHC-P starting dilution is: 1:10~50
Type: Primary
Antigen: PDP1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: Rabbit Ig
Reactivity: Human, Rat