- Antibody Type:Primary
- Antigen Name:Transient receptor potential cation channel subfamily M member 8
- Antigen Symbol:TRPM8
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Reactivity:Human
- Western Blot:Yes
- Size:400 ul
- Epitope:Amino Acid Range = 263-292
- Form:Liquid
- Gene ID:Q7Z2W7
- Antigen Synonyms:TRPM8
- Modification:None
- Storage Buffer:Supplied in PBS with 0.09% (W/V) sodium azide.
- Molecular Weight:128 kDa
- Storage Temperature:Store at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:2 mg/mL
- Shipping Temperature:4 °C
- Immunogen:This TRPM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the Central region of human TRPM8.
- Purification:This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
- Cat. No.:76011-120
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
- For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100 For IF starting dilution is: 1:10~50
Type: Primary
Antigen: TRPM8
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: Rabbit Ig
Reactivity: Human