Specifications
- Antibody Type:Primary
- Antigen Name:Histone-lysine N-methyltransferase 2A
- Antigen Symbol:KMT2A
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Flow Cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Reactivity:Human
- Size:400 ul
- Epitope:Amino Acid Range = 3879-3908
- Form:Liquid
- Gene ID:Q03164
- Antigen Synonyms:KMT2A
- Modification:None
- Storage Buffer:Supplied in PBS with 0.09% (W/V) sodium azide.
- Molecular Weight:432 kDa
- Storage Temperature:Store at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:2 mg/mL
- Shipping Temperature:4 °C
- Immunogen:This HRX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3879-3908 amino acids from the C-terminal region of human HRX.
- Purification:This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
- Cat. No.:76010-342
Specifications
About this item
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. Tse et al. (1995) characterized 2 t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21, AF1Q, in 2 infants with acute myelomonocytic leukemia. In one of these patients, the derivative chromosome 11 represented an in-frame fusion of the N-terminal portion of the MLL gene to the complete AF1Q open reading frame, whereas the derivative chromosome 1 did not give rise to an open reading frame. This observation suggested that the N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23.
For FACS starting dilution is: 1:10~50 For IHC-P starting dilution is: 1:50~100
Type: Primary
Antigen: KMT2A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: Rabbit Ig
Reactivity: Human