Tight-binding, reversible, highly selective inhibitor of acid proteases (aspartyl peptidases), like pepsin, gastricsin, cathepsin E and D, renin, chymosin, bacterial aspartic proteinases and HIV proteases. Does not inhibit thiol proteases, neutral proteases or serine proteases. Widely used as a research tool in studies of protease mechanisms and biological functions. Solubilized gamma-secretase and retroviral protease inhibitor. Shows antibacterial, antifungal and antiparasitic activity. Suppresses p53-dependent apoptosis in lymphoid cells as well as TNFalpha-induced apoptosis in U937 cells. Inhibits degradation of autophagic cargo inside autophagolysosomes.
- Soluble in DMSO, methanol or acetic acid
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- CAS No.:26305-03-3
- Protein/Peptide Type:Synthetic
- Source:Synthetic
- Storage Conditions:Freezer
- Protein/Peptide Name:Pepstatin A
- Purity:>98% (HPLC)
- Molecular Weight:685.9
- Sequence:Iva-Val-Val-Sta-Ala-Sta
- Formulation:White to off-white powder.
- Molecular Formula:C₃₄H₆₃N₅O₉