About this item
Cell permeable, non-selective broad-spectrum caspase inhibitor. Binds irreversibly to the catalytic site of caspase proteases. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Potent inhibitor of caspase-1 activation in NLRP3/NALP3-induced cells. Used in apoptosis and inflammasome studies.
- White solid
- Soluble in DMSO, acetonitrile or dimethyl formamide
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Specifications
- Source:Synthetic
- Storage Conditions:Freezer
- Protein/Peptide Name:Z-Val-Ala-Asp(OMe)-fluoromethyl ketone
- Purity:>95% (HPLC)