Afatinib ≥95%
About this item
Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC(50) values ranging from approximately 6nM to below 500nM.
- CAS Number:850140-72-6
- Formula:C₂₄H₂₅ClFN₅O₃
- MDL Number:MFCD12407405
- Molecular Weight:485.94 g/mol
- Storage Temperature:Freezer
4 Options Available Below
- Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
- Return Policy
Product Details & Documents
Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC(50) values ranging from approximately 6nM to below 500nM.
- CAS Number:850140-72-6
- Formula:C₂₄H₂₅ClFN₅O₃
- MDL Number:MFCD12407405
- Molecular Weight:485.94 g/mol
- Storage Temperature:Freezer
Specifications for Product Family
Specification Test Results
- Purity:>95%
- Appearance/Color:Solid.
- Solubility:Soluble in DMSO or ethanol.
Product Family Options
Product Information
- Pack typeSizeAvailabilityPrice
- Supplier Number: SYN-1100-M001Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:MarketsourceMarketsource
- Supplier Number: SYN-1100-M005Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:MarketsourceMarketsource
- Supplier Number: SYN-1100-M010Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:MarketsourceMarketsource
- Supplier Number: SYN-1100-M050Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:MarketsourceMarketsource
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