Danusertib ≥95%
IrritantAbout this item
Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid tumors. Danusertib (PHA-739358) is a small molecule pan- Aurora kinase inhibitor that also has activity against other cancer-relevant kinases such as Bcr-Abl tyrosine kinase. Other off target effects of danusertib include inhibition of receptor tyrosine kinases such as FGFR-1, and TrkA. Danusertib demonstrates nanomolar IC(50) values for the Aurora kinases all under 100nM and it also demonstrates potent anti-proliferation effects in cell proliferation assays with IC(50) values ranging from 20nM for A2780 cells to 200nM.
- CAS Number:827318-97-8
- Formula:C₂₆H₃₀N₆O₃
- MDL Number:MFCD12024692
- Molecular Weight:474.6 g/mol
- Storage Temperature:Freezer
4 Options Available Below
- Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
- Return Policy
Product Details & Documents
Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid tumors. Danusertib (PHA-739358) is a small molecule pan- Aurora kinase inhibitor that also has activity against other cancer-relevant kinases such as Bcr-Abl tyrosine kinase. Other off target effects of danusertib include inhibition of receptor tyrosine kinases such as FGFR-1, and TrkA. Danusertib demonstrates nanomolar IC(50) values for the Aurora kinases all under 100nM and it also demonstrates potent anti-proliferation effects in cell proliferation assays with IC(50) values ranging from 20nM for A2780 cells to 200nM.
- CAS Number:827318-97-8
- Formula:C₂₆H₃₀N₆O₃
- MDL Number:MFCD12024692
- Molecular Weight:474.6 g/mol
- Storage Temperature:Freezer
Specifications for Product Family
Specification Test Results
- Purity:95%
- Appearance/Color:Solid.
- Solubility:Soluble in DMSO or ethanol.
Specifications
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- Supplier Number: SYN-1095-M001Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:Marketsource
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Cat. No.102992-004Marketsource - Supplier Number: SYN-1095-M005Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:Marketsource
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Cat. No.102992-006Marketsource - Supplier Number: SYN-1095-M010Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:Marketsource
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Cat. No.102992-008Marketsource - Supplier Number: SYN-1095-M050Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:Marketsource
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Cat. No.102992-010Marketsource
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