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Specifications
- Antibody Type:Primary
- Antigen Name:CD28
- Antigen Symbol:CD28
- Clonality:Monoclonal
- Clone:AV7
- Conjugation:Biotin
- Flow Cytometry:Yes
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG1
- Reactivity:Turkey,Chicken
- Size:0.5 mg
- Form:Liquid
- Gene ID:396249
- Storage Buffer:Supplied in PBS/NaN3
- Storage Temperature:2-8°C
- Concentration:0.5 mg/mL
- Shipping Temperature:Ambient Temperature
- Immunogen:Chicken peripheral blood lymphocytes
- Cat. No.:100245-472
- Supplier no.:8260-08
Specifications
About this item
Chicken CD28 antigen is a type I transmembrane monomeric glycoprotein which does not contain the cysteine residues that form disulfide-linked covalent homodimers found in the mammalian counterpart. This may reduce the avidity of binding to individual ligand molecules expected to be present on antigen presenting cells. Peripheral γδ+ T cells are CD28 negative. Monoclonal antibodies against CD28 have a costimulatory effect on T cells stimulated by phorbol myristate acetate (PMA), concanavalin A, or monoclonal antibodies against the avian T cell receptor (TCR). Both Vβ1- and Vβ2-expressing cells respond equally well to stimulation with anti-CD28 in combination with PMA. These responses are resistant to cyclosporin A but inhibited by herbimycin A suggesting that CD28 employs a signaling pathway at least partly distinct from that triggered by TCR/CD3. The monoclonal antibody AV7 also reacts with turkey CD28 as demonstrated by flow cytometry.
Type: Primary
Antigen: CD28
Clonality: Monoclonal
Clone: AV7
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Chicken, Turkey