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Specifications
- Cell Format:Cryopreserved
- Description:Peripheral Blood CD4+/CD25+/CD127- Regulatory T Cells
- Size:2 x 106 Cells
- Environmentally Preferable:
- Cat. No.:103051-102
- Supplier no.:PB425/127NC-2
Specifications
About this item
Regulatory T cells were isolated from leukapheresis product by CD127 depletion and positive selection using CD25 immunomagnetic beads.
- Express intracellular transcription factor FoxP3
- Critical to the maintenance of immune cell homeostasis and peripheral tolerance
- Isolated from leukapheresis product by CD127 depletion and positive selection
CD4+/CD25+/CD127- Regulatory T Cells (or dim Regulatory T Cells) express intracellular transcription factor FoxP3. They are critical to the maintenance of immune cell homeostasis and peripheral tolerance. Precise understanding of the immunosuppressive mechanism of Regulatory T Cells remain elusive, including the secretion of immunosuppressive soluble factors such as IL-9, IL-10 and TGF beta, cell contact mediated regulation via the high affinity TCR, and other costimulatory molecules such as CTLA-4, GITR, and cytolytic activity, among others. Understanding the mechanisms of T Reg Cells brings broad implications for the development of therapeutic strategies for many disease processes, including cancer, diabetes, and immune mediated diseases.