Some Products May Appear Restricted
To ensure a smooth and speedy checkout, please log in to your account. Some items may show as restricted simply because you're not logged in.
If you do not have an account, you can register using our registration webform (https://www.avantorsciences.com/us/en/login/register)
If you're still seeing restrictions after logging in, certain products—like chemicals or medical devices—require additional account verification steps to be able to place an order. Some items may additionally require a specific license or customer documentation; additional documentation will be requested for these items prior to shipment.
- Cell Format:Cryopreserved
- Description:Peripheral Blood CD4+/CD25+/CD127- Regulatory T Cells
- Size:2 x 106 Cells
- Cat. No.:103051-102
- Supplier no.:PB425/127NC-2
Regulatory T cells were isolated from leukapheresis product by CD127 depletion and positive selection using CD25 immunomagnetic beads.
- Express intracellular transcription factor FoxP3
- Critical to the maintenance of immune cell homeostasis and peripheral tolerance
- Isolated from leukapheresis product by CD127 depletion and positive selection
CD4+/CD25+/CD127- Regulatory T Cells (or dim Regulatory T Cells) express intracellular transcription factor FoxP3. They are critical to the maintenance of immune cell homeostasis and peripheral tolerance. Precise understanding of the immunosuppressive mechanism of Regulatory T Cells remain elusive, including the secretion of immunosuppressive soluble factors such as IL-9, IL-10 and TGF beta, cell contact mediated regulation via the high affinity TCR, and other costimulatory molecules such as CTLA-4, GITR, and cytolytic activity, among others. Understanding the mechanisms of T Reg Cells brings broad implications for the development of therapeutic strategies for many disease processes, including cancer, diabetes, and immune mediated diseases.