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Specifications
- Host:
- Primary antibody reactivity:Mouse
- Target protein:RBP4
- Description:RBP4 Mouse/Rat ELISA
- Size:1 kit
- Environmentally Preferable:
- Regulatory Status:RUO
- Cat. No.:102552-688
- Supplier no.:RAG007R
Specifications
About this item
Retinol binding protein (RBP) 4 is the only specific transport protein for vitamin A in the circulation whose function is to deliver vitamin to target tissues.
- Calibration Range: 0.188-12 ng/mL
- Limit of Detection: 60 pg/mL
- Cell culture supernatant, Serum, Urine: sample diluiton will need to be determined, start at 10,000x dilution for serum and 10x for urine
Retinol binding protein (RBP) 4 is the only specific transport protein for vitamin A in the circulation whose function is to deliver vitamin to target tissues (1). In obesity and type 2 diabetes, expression of Glut4 is significantly impaired in adipocytes. Glucose transport via Glut4 is the rate-limiting step for glucose use by muscle and adipose tissue (2). Yang et al. noted that adipocyte-specific deletion of Gluts led to notable elevation of RBP4 causing systemic insulin resistance, and that reduction of RBP4 improved insulin resistance (3). This identified a novel role of RBP4 in regulating insulin action and RBP4 is recorded as an adipocyte-derived hormone. Thus, measurement of serum or plasma RBP4 is a useful means for understanding of metabolic disorders.