About this item
Follistatin is an autocrine, activin-binding protein that is ubiquitously expressed with highest expression levels being in the ovary and skin. Follistatin negatively regulates the signaling of transforming growth factor beta (TGF-β) family members, such as activin, bone morphogenetic proteins (BMPs), myostatin, growth differentiation factor 11 (GDF-11), and TGF-β1.
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Follistatin functions as an antagonist by binding TGF-β family members to block interaction with their signaling receptors. Follistatin also inhibits the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary.
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Specifications
- Conjugation:Unconjugated
- Protein Function:Cytokine
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Mouse
- Storage Conditions:−20 °C
- Endotoxin Content:Endotoxin LAL (EU/µg) ≤1
- Biological Activity:Bioactivity assay: TF-1 cell proliferation, ED50 ≤2 ng/ml, bioactivity ≥5.0×10⁵ units/mg
- Gene ID:P04401
- Reconstitution Instructions:Sterile water at 0.1 mg/ml
- Endotoxin-free:N
- Carrier-Free:Y
- Protease-free:N
- Animal-Free:Y
- Protein Synonyms:EDF|TRF|BCDFII
- UniProtKB:P04401
- Protein/Peptide Name:IL-5 (AF)
- Purity:≥95%
- Molecular Weight:13.1/26.3 kDa
- Sequence:MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG
- Endotoxin Level:Low
- Formulation:20 mM sodium bicarbonate, pH 9.0
- Nuclease-free:N
- Grade:RUO
- Shipping Temperature:RT
- Tested Applications:Bioassay