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- Primary antibody reactivity:Human
- Description:Lecithin-Cholesterol Acyltransferase (LCAT) Human ELISA
- Size:1 kit
- Regulatory Status:RUO
- Cat. No.:101076-614
- Supplier no.:RD191122200R
Human Lecithin: cholesterol acyltransferase (LCAT) is a glycoprotein with a molecular mass of approximately 58 kDa.
- Calibration Range: 2.5-160 ng/mL
- Limit of Detection: 0.27 ng/mL
- Cerebrospinal fluid, Plasma-Citrate, Plasma-EDTA, Serum: (serum and plasma) 5uL/well (CSF) 10uL/well
Human Lecithin: cholesterol acyltransferase (LCAT) is a glycoprotein with a molecular mass of approximately 58 kDa. It is the key enzyme responsible for esterification of free cholesterol to cholesteryl esters in circulating plasma lipoproteins, primarily in high density lipoprotein (HDL). The tertiary structure of LCAT is maintained by two disulfide bridges, similar to lipases and other proteins of the α/β hydrolase fold family. Mature LCAT protein is synthesized from a 440 residue precursor by following cleavage of a 24 residue signal peptide. The mature protein contains 416 amino acids and is heavily N-glycosylated. LCAT is abundant in blood plasma and it is present in other organs, including liver, brain and testes. In plasma LCAT is associated with ApoD which frequently co-purify. A recent study suggests that LCAT can act as an antioxidant and prevent the accumulation of oxidized lipid in plasma lipoproteins. LCAT performs a central role in HDL metabolism by catalyzing the formation of cholesteryl esters on HDL through the transfer of fatty acids from the sn-2 positions of phosphatidylcholine (PC) to cholesterol. The role of LCAT in atherosclerosis is unclear.