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Specifications
- Primary antibody reactivity:Mouse
- Target protein:IL-15R/IL-15 Complex
- Description:Interleukin-15/Interleukin-15 Receptor (IL-15/IL-15R) Mouse ELISA
- Size:1 kit
- Regulatory Status:RUO
- Cat. No.:102552-322
- Supplier no.:RAF037R
Specifications
About this item
Interleukin-15 (IL-15) is a 14 kDa proinflammatory protein that is essential to the development and survival of NK cells and CD8 T-cells.
- Calibration Range: 6.3-400 pg/mL
- Limit of Detection: 2 pg/mL
- Cell culture supernatant, Plasma-EDTA, Serum: 50 uL/well
Interleukin-15 (IL-15) is a 14 kDa proinflammatory protein that has been shown to play a role in the activation of neutrophils, dendritic cells, and macrophages, and is essential to the development and survival of NK cells and CD8 T-cells. IL-15 activates Jak/Stat pathways by signaling through a heterotrimeric receptor. Two of the subunits of this receptor, β and γ, are shared with the IL-2 receptor, while the α subunit is unique to IL-15. Despite the expression of IL-15 mRNA in many cell types, the secreted protein is rarely detectable in biological samples. Recent research suggests that IL-15 is retained inside the cell and is only secreted in complex with its unique receptor, IL-15Rα. This chaperoning is required from the ER to Golgi through to secretion. The cytokine/receptor complex may stay bound to the cell surface, where it can be transpresented to cells expressing the βγ subunits of the receptor, or may be secreted in a soluble form that lacks the transmembrane domain of the receptor. The soluble IL-15/IL-15R complex is produced by mouse dendritic cells, fibroblasts, and macrophages, and demonstrates a 10– 100-fold increase in agonistic activity over IL-15 alone.