To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:
- • State issued document with your organization's Federal Tax ID Number
- • State issued document with your organization's Resale Tax ID Number
- • City or County issued Business License
- • State Department of Health Services License
- • Any other ID issued by the State that includes the business name & address
* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. Avantor will not lift restrictions for residential shipping addresses.
- Primary antibody reactivity:Mouse
- Target protein:IL-15R/IL-15 Complex
- Description:Interleukin-15/Interleukin-15 Receptor (IL-15/IL-15R) Mouse ELISA
- Size:1 kit
- Regulatory Status:RUO
- Cat. No.:102552-322
- Supplier no.:RAF037R
Interleukin-15 (IL-15) is a 14 kDa proinflammatory protein that is essential to the development and survival of NK cells and CD8 T-cells.
- Calibration Range: 6.3-400 pg/mL
- Limit of Detection: 2 pg/mL
- Cell culture supernatant, Plasma-EDTA, Serum: 50 uL/well
Interleukin-15 (IL-15) is a 14 kDa proinflammatory protein that has been shown to play a role in the activation of neutrophils, dendritic cells, and macrophages, and is essential to the development and survival of NK cells and CD8 T-cells. IL-15 activates Jak/Stat pathways by signaling through a heterotrimeric receptor. Two of the subunits of this receptor, β and γ, are shared with the IL-2 receptor, while the α subunit is unique to IL-15. Despite the expression of IL-15 mRNA in many cell types, the secreted protein is rarely detectable in biological samples. Recent research suggests that IL-15 is retained inside the cell and is only secreted in complex with its unique receptor, IL-15Rα. This chaperoning is required from the ER to Golgi through to secretion. The cytokine/receptor complex may stay bound to the cell surface, where it can be transpresented to cells expressing the βγ subunits of the receptor, or may be secreted in a soluble form that lacks the transmembrane domain of the receptor. The soluble IL-15/IL-15R complex is produced by mouse dendritic cells, fibroblasts, and macrophages, and demonstrates a 10– 100-fold increase in agonistic activity over IL-15 alone.