- Protein/Peptide Type:Recombinant
- Source:CHO cells
- Species:Human
- Size:25 μg
- Tag sequence:Fc Tag
- Storage Conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Protein Synonyms:IL-12p70|NKSF|Cytotoxic Lymphocyte Maturation Factor|CLMF|TSF|T-cell Stimulatory Factor|IL-12p75|Interleukin-12|Natural Killer Cell Stimulatory Factor
- Protein/Peptide Name:IL12
- Purity:>98% (SDS-PAGE)
- Sequence:57-253
- Formulation:Lyophilized from 0.2um-filtered solution in PBS.
- Cat. No.:75794-366
- Supplier no.:90-502
Interleukin-12 (IL-12), also known as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and Natural Killer (NK) cells. Some of these IL-12 activities include the induction of IFN-gamma and TNF in resting and activated T and NK cells; the enhancement of cytotoxic activity of resting NK and T cells, the stimulation of resting T cell proliferation in the presence of a comitogen; and the enhancement of NK cell proliferation. Current evidence indicates that IL-12 is a key mediator of cellular immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been suggested that IL-12 may have therapeutic potential as a vaccine adjuvant that promotes cellular immunity and as an antitumor and anti viral agent.
- Fusion-Tag: Fc Tag
This recombinant proteins is for research use only.