Specifications
- Protein/Peptide Type:Recombinant
- Source:CHO cells
- Species:Human
- Size:100 μg
- Tag sequence:Fc Tag
- Storage Conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Protein Synonyms:PD-1|Programmed Cell Death Protein 1
- Protein/Peptide Name:CD279
- Purity:>98% (SDS-PAGE)
- Sequence:25-167
- Formulation:Lyophilized from 0.2um-filtered solution in PBS.
- Cat. No.:75794-360
- Supplier no.:90-447
Specifications
About this item
Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
- Fusion-Tag: Fc Tag
This recombinant proteins is for research use only.