Specifications
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Size:10 μg
- Tag sequence:His Tag
- Storage Conditions:Working aliquots are stable for up to 3 months when stored at −20 °C.
- Biological Activity:>2U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1umol of NAD+ per min.
- Protein Synonyms:Nicotinamide Mononucleotide Adenylyltransferase 3|NMN Adenylyltransferase 3|NaMN Adenylyltransferase 3|EC 2.7.7.1|EC 2.7.7.18
- Protein/Peptide Name:NMNAT3 (highly active)
- Purity:>95% (SDS-PAGE)
- Sequence:1-252
- Formulation:Liquid, In 50mM TRIS-HCl, pH 8.0, containing 300mM sodium chloride, 1mM DTT and 10% glycerol.
- Cat. No.:75794-306
- Supplier no.:90-356
Specifications
About this item
Mitochondrial NMNAT isoform. Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. Can use tiazofurin monophosphate as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i. e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity, mitochondrial NMNAT isoform can use NAD(+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NAADP+. Protects against axonal degeneration following injury.
- Fusion-Tag: His Tag
This recombinant proteins is for research use only.