Mouse Recombinant FGF21 (from HEK293 Cells)
- Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
- Return Policy
Product Details & Documents
Fibroblast growth factor 21 (FGF-21) is a member of the fibroblast growth factor family and has been identified as an important regulator of energy metabolism connecting nutrition, growth, reproduction and longevity. FGF-21 lacks the heparin-binding domain of most FGF proteins, allowing its secretion. FGF-21 is abundantly expressed in adipose tissues, liver and pancreas. In adipose tissue, FGF-21 promotes glucose uptake and oxidation and in liver it replenishes on fasting the tissues with fuel on low nutritional supply. It also induces lipolysis and ketogenesis. FGF-21 acts through FGF receptors (FGFR) associated with the auxiliary protein beta-Klotho. Recently, FGF-21 has been reported to interact directly with the brain circadian clock to coordinate activity and reproduction as part of the adaptation to fasting. Due to its multiple functions of normalizing glucose, lipid and energy homeostasis, FGF-21 represents an attractive novel therapy for type 2 diabetes mellitus and obesity.
- Fusion-Tag: DDDDK Tag
This recombinant proteins is for research use only.
Documents
75793-848.pdf
Datasheet
Specifications
Specifications
- Size:10 μg
- Storage Conditions:Stable for at least 6 months after receipt when stored at −20 °C.
- Cat. No.:75793-848
- Protein/Peptide Type:Recombinant
- Formulation:Lyophilized, Contains PBS.
- Purity:>95% (SDS-PAGE)
- Tested Applications:Research
- Protein Synonyms:Fibroblast Growth Factor-21|FGFL
- Protein/Peptide Name:FGF21
- Tag sequence:DDDDK Tag
- Sequence:29-210
- Species:Mouse
- Source:HEK293 cells
Specifications
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