Mouse Recombinant IL36 beta (from E. coli)
Catalog # 75794-072
Supplier: Prosci
CAS Number:
Specifications
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Mouse
- Size:10 μg
- Tag sequence:Tag Free
- Storage Conditions:Stable for at least 6 months after receipt when stored at −20 °C.
- Biological Activity:Induces secretion of IL-6 in BMDCs at a concentration of 10 - 100ng/ml.
- Protein Synonyms:IL-1F8|Interleukin-1 Family Member 8|Interleukin-36beta
- Protein/Peptide Name:IL36 beta
- Purity:>95% (SDS-PAGE)
- Sequence:Ser31-Lys183
- Formulation:Lyophilized, Contains PBS + 0.5% Trehalose.
- Cat. No.:75794-072
- Supplier no.:90-283
Specifications
About this item
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
- Fusion-Tag: Tag Free
This recombinant proteins is for research use only.