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Mouse Recombinant IL36 alpha (from E. coli)
Mouse Recombinant IL36 alpha (from E. coli)
  75794-070
 :  Prosci
 :  
Mouse Recombinant IL36 alpha (from E. coli)
  75794-070
 :  Prosci
 :  90-282
 :  
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  • Protein/Peptide Type:
    Recombinant
  • Source:
    E. coli
  • Species:
    Mouse
  • Size:
    10 μg
  • Tag sequence:
    Tag Free
  • Storage Conditions:
    Stable for at least 6 months after receipt when stored at −20 °C.
  • Biological Activity:
    Induces secretion of IL-6 in BMDCs at a concentration of 100ng - 1ug/ml.
  • Protein Synonyms:
    Interleukin-1 Family Member 6|Interleukin-36alpha|IL-1H1|Interleukin-1epsilon|FIL1epsilon|IL-1F6|Interleukin-1 Homolog 1
  • Protein/Peptide Name:
    IL36 alpha
  • Purity:
    >95% (SDS-PAGE)
  • Sequence:
    Arg8-His160
  • Formulation:
    Lyophilized, Contains PBS.
  • Cat. No.:
    75794-070
  • Supplier no.:
    90-282

 

 

IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

  • Fusion-Tag: Tag Free

This recombinant proteins is for research use only.