Specifications
- Protein/Peptide Type:Recombinant
- Source:HEK293 cells
- Species:Human
- Size:10 μg
- Tag sequence:DDDDK Tag
- Storage Conditions:Stable for at least 6 months after receipt when stored at −20 °C.
- Biological Activity:Stimulates B cell proliferation.
- Protein Synonyms:ACRP30headless:TNFSF13|ACRP30headless:APRIL|ACRP30headless:A-proliferation-inducing Ligand:|ACRP30headless:CD256
- Protein/Peptide Name:APRIL multimeric
- Purity:>95% (SDS-PAGE)
- Sequence:18-110
- Formulation:Lyophilized, Contains PBS + 0.5% Trehalose.
- Cat. No.:75794-052
- Supplier no.:90-273
Specifications
About this item
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.
- Fusion-Tag: DDDDK Tag
This recombinant proteins is for research use only.