Specifications
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Size:10 μg
- Tag sequence:His Tag
- Storage Conditions:Working aliquots are stable for up to 3 months when stored at −20 °C.
- Biological Activity:Activates mouse and human ST2-dependent NF-kappaB pathway.
- Protein Synonyms:IL-1F11|NF-HEV|Interleukin-33
- Protein/Peptide Name:IL33
- Purity:>90% (SDS-PAGE)
- Sequence:109-266
- Formulation:0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
- Cat. No.:75793-600
- Supplier no.:90-047
Specifications
About this item
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
- Fusion-Tag: His Tag
This recombinant proteins is for research use only.