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Human Recombinant PDL1 (from Cells)
Human Recombinant PDL1 (from Cells)
Catalog # 75791-760
Supplier:  Prosci
CAS Number:  
Human Recombinant PDL1 (from Cells)
Catalog # 75791-760
Supplier:  Prosci
Supplier Number:  92-599
CAS Number:  

Specifications

  • Protein/Peptide Type:
    Recombinant
  • Source:
    Cells
  • Species:
    Human
  • Size:
    0.05 mg
  • Tag sequence:
    C-mFc tag
  • Storage Conditions:
    Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
  • Endotoxin Content:
    <0.1 ng/ug (1 IEU/ug) as determined by LAL test.
  • Protein Synonyms:
    PDL1|B7-H1|PD-L1|Programmed Cell Death 1 Ligand 1|B7H1|B7 Homolog 1|PDCD1 Ligand 1|CD274|PDCD1L1|Programmed Death Ligand 1|PDCD1LG1
  • Protein/Peptide Name:
    PDL1
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Molecular Weight:
    50.9 kD
  • Sequence:
    Phe19-Thr239
  • Formulation:
    Lyophilized from a 0.2 um filtered solution of PBS,pH7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Cat. No.:
    75791-760
  • Supplier no.:
    92-599

Specifications

About this item

CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

  • Fusion-Tag: C-mFc tag

This recombinant protein can be used for biological assays. For research use only.