Mouse Recombinant PDCD1
- Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
- Return Policy
Product Details & Documents
Programmed Death-1 (PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating. Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner. PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.
- Fusion-Tag: C-6 His tag
This recombinant protein can be used for biological assays. For research use only.
Documents
75791-562.pdf
Datasheet
Specifications
Specifications
- Size:0.05 mg
- Storage Conditions:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Cat. No.:75791-562
- Molecular Weight:17.2 kD
- Protein/Peptide Type:Recombinant
- Formulation:Lyophilized from a 0.2 um filtered solution of 20mM Tris,150mM NaCl,pH8.0. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Purity:> 95% as determined by reducing SDS-PAGE
- Protein Synonyms:PD-1|mPD-1|CD279|Pdcd1|Programmed Cell Death protein 1
- Protein/Peptide Name:PDCD1
- Tag sequence:C-6 His tag
- Endotoxin Content:<0.1 ng/ug (1 IEU/ug) as determined by LAL test.
- Sequence:Leu25-Gln167
- Species:Mouse
Specifications
Recommendations will be personalized based on your shopping preferences only if you have given your consent by enabling "Enhance my Shopping Experience" on the "Personal Info page".
Otherwise, you will receive generic recommendations.