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Human Recombinant PIP4K2A (from Cells)
Human Recombinant PIP4K2A (from Cells)
  75791-442
 :  Prosci
 :  
Human Recombinant PIP4K2A (from Cells)
  75791-442
 :  Prosci
 :  92-436
 :  

 

  • Protein/Peptide Type:
    Recombinant
  • Source:
    Cells
  • Species:
    Human
  • Size:
    0.05 mg
  • Tag sequence:
    C-6 His tag
  • Storage Conditions:
    Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
  • Endotoxin Content:
    <0.1 ng/ug (1 IEU/ug) as determined by LAL test.
  • Protein Synonyms:
    Phosphatidylinositol 5-phosphate 4-kinase type II alpha|PtdIns(4)P-5-kinase B isoform|1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha|PtdIns(5)P-4-kinase isoform 2-alpha|PIP5KIII|PtdIns(4)P-5-kinase C isoform|Diphosphoinositide kinase 2-alpha
  • Protein/Peptide Name:
    PIP4K2A
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Molecular Weight:
    47.3 kD
  • Sequence:
    Met1-Thr406
  • Formulation:
    Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl,pH7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested Applications:
    Bioassay
  • Cat. No.:
    75791-442
  • Supplier no.:
    92-436

 

 

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. It may regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation, negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. It also involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.

  • Fusion-Tag: C-6 His tag

This recombinant protein can be used for biological assays. For research use only.