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Mouse Recombinant Death Receptor 6
Mouse Recombinant Death Receptor 6
Catalog # 75790-536
Supplier:  Prosci
CAS Number:  
Mouse Recombinant Death Receptor 6
Catalog # 75790-536
Supplier:  Prosci
Supplier Number:  91-950
CAS Number:  

Specifications

  • Protein/Peptide Type:
    Recombinant
  • Species:
    Mouse
  • Size:
    0.05 mg
  • Tag sequence:
    C-Fc-6 His tag
  • Storage Conditions:
    Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
  • Endotoxin Content:
    <0.1 ng/ug (1 IEU/ug) as determined by LAL test.
  • Protein Synonyms:
    Tumor necrosis factor receptor superfamily member 21|Death receptor 6|DR6|CD358|BM-018|Tnfrsf21
  • Protein/Peptide Name:
    Death Receptor 6
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Molecular Weight:
    64.7 kD
  • Sequence:
    Gln42-His349
  • Formulation:
    Lyophilized from a 0.2 um filtered solution of PBS,pH7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested Applications:
    Bioassay
  • Cat. No.:
    75790-536
  • Supplier no.:
    91-950

Specifications

About this item

Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

  • Fusion-Tag: C-Fc-6 His tag

This recombinant protein can be used for biological assays. For research use only.