Mouse Recombinant Death Receptor 6
Catalog # 75790-536
Supplier: Prosci
CAS Number:
Specifications
- Protein/Peptide Type:Recombinant
- Species:Mouse
- Size:0.05 mg
- Tag sequence:C-Fc-6 His tag
- Storage Conditions:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Endotoxin Content:<0.1 ng/ug (1 IEU/ug) as determined by LAL test.
- Protein Synonyms:Tumor necrosis factor receptor superfamily member 21|Death receptor 6|DR6|CD358|BM-018|Tnfrsf21
- Protein/Peptide Name:Death Receptor 6
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular Weight:64.7 kD
- Sequence:Gln42-His349
- Formulation:Lyophilized from a 0.2 um filtered solution of PBS,pH7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested Applications:Bioassay
- Cat. No.:75790-536
- Supplier no.:91-950
Specifications
About this item
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
- Fusion-Tag: C-Fc-6 His tag
This recombinant protein can be used for biological assays. For research use only.