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Human Recombinant Dickkopf-related 1 (from Cells)
Human Recombinant Dickkopf-related 1 (from Cells)
Catalog # 75789-822
Supplier:  Prosci
CAS Number:  
Human Recombinant Dickkopf-related 1 (from Cells)
Catalog # 75789-822
Supplier:  Prosci
Supplier Number:  91-573
CAS Number:  

Specifications

  • Protein/Peptide Type:
    Recombinant
  • Source:
    Cells
  • Species:
    Human
  • Size:
    0.05 mg
  • Tag sequence:
    N-8 His tag
  • Storage Conditions:
    Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
  • Endotoxin Content:
    <0.1 ng/ug (1 IEU/ug) as determined by LAL test.
  • Protein Synonyms:
    Dickkopf-related protein 1|Dickkopf-1|Dkk-1
  • Protein/Peptide Name:
    Dickkopf-related 1
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Molecular Weight:
    27 kD
  • Sequence:
    Thr32-His266
  • Formulation:
    Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested Applications:
    Bioassay
  • Cat. No.:
    75789-822
  • Supplier no.:
    91-573

Specifications

About this item

Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

  • Fusion-Tag: N-8 His tag

This recombinant protein can be used for biological assays. For research use only.