Human Recombinant PHS (from E. coli)
75789-168
: Prosci
:
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Size:0.05 mg
- Tag sequence:N-6 His tag
- Storage Conditions:Store at −20 °C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Endotoxin Content:<0.1 ng/ug (1 IEU/ug) as determined by LAL test.
- Protein Synonyms:Dimerization Cofactor of HNF1|Pterin-4-Alpha-Carbinolamine Dehydratase|Phenylalanine Hydroxylase-Stimulating Protein|PCBD|PCBD1|Pterin Carbinolamine Dehydratase|Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha|PCD|PHS|4-Alpha-Hydroxy-Tetrahydropterin Dehydratase|DCoH
- Protein/Peptide Name:PHS
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular Weight:14.2 kD
- Sequence:Ala2-Thr104
- Formulation:Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, 1mM DTT, pH 8.0. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested Applications:Bioassay
- Cat. No.:75789-168
- Supplier no.:91-226
Pterin-4- alpha-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4- alpha-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.
- Fusion-Tag: N-6 His tag
This recombinant protein can be used for biological assays. For research use only.