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Human Recombinant PHS (from E. coli)
Human Recombinant PHS (from E. coli)
Catalog # 75789-168
Supplier:  Prosci
CAS Number:  
Human Recombinant PHS (from E. coli)
Catalog # 75789-168
Supplier:  Prosci
Supplier Number:  91-226
CAS Number:  

Specifications

  • Protein/Peptide Type:
    Recombinant
  • Source:
    E. coli
  • Species:
    Human
  • Size:
    0.05 mg
  • Tag sequence:
    N-6 His tag
  • Storage Conditions:
    Store at −20 °C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
  • Endotoxin Content:
    <0.1 ng/ug (1 IEU/ug) as determined by LAL test.
  • Protein Synonyms:
    Dimerization Cofactor of HNF1|Pterin-4-Alpha-Carbinolamine Dehydratase|Phenylalanine Hydroxylase-Stimulating Protein|PCBD|PCBD1|Pterin Carbinolamine Dehydratase|Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha|PCD|PHS|4-Alpha-Hydroxy-Tetrahydropterin Dehydratase|DCoH
  • Protein/Peptide Name:
    PHS
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Molecular Weight:
    14.2 kD
  • Sequence:
    Ala2-Thr104
  • Formulation:
    Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, 1mM DTT, pH 8.0. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested Applications:
    Bioassay
  • Cat. No.:
    75789-168
  • Supplier no.:
    91-226

Specifications

About this item

Pterin-4- alpha-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4- alpha-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.

  • Fusion-Tag: N-6 His tag

This recombinant protein can be used for biological assays. For research use only.