Human Recombinant Bc1-w (from E. coli)
Catalog # 75788-900
Supplier: Prosci
CAS Number:
Specifications
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Size:0.05 mg
- Tag sequence:C-6 His tag
- Storage Conditions:Store at −20 °C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Endotoxin Content:<0.1 ng/ug (1 IEU/ug) as determined by LAL test.
- Protein Synonyms:Bcl-2-like Protein 2|Bcl2-L-2|BCL2L2|Bcl-2-Llike Protein 2|Apoptosis Regulator Bcl-W|KIAA0271|BCLW
- Protein/Peptide Name:Bc1-w
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular Weight:19.87 kD
- Sequence:Ala2-Thr172
- Formulation:Supplied as a 0.2 um filtered solution of 25mM HEPES, 100mM KCl, 20% Glycerol, pH 7.5. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested Applications:Bioassay
- Cat. No.:75788-900
- Supplier no.:91-088
Specifications
About this item
Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
- Fusion-Tag: C-6 His tag
This recombinant protein can be used for biological assays. For research use only.