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Human Recombinant Bc1-w (from E. coli)
Human Recombinant Bc1-w (from E. coli)
Catalog # 75788-900
Supplier:  Prosci
CAS Number:  
Human Recombinant Bc1-w (from E. coli)
Catalog # 75788-900
Supplier:  Prosci
Supplier Number:  91-088
CAS Number:  

Specifications

  • Protein/Peptide Type:
    Recombinant
  • Source:
    E. coli
  • Species:
    Human
  • Size:
    0.05 mg
  • Tag sequence:
    C-6 His tag
  • Storage Conditions:
    Store at −20 °C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
  • Endotoxin Content:
    <0.1 ng/ug (1 IEU/ug) as determined by LAL test.
  • Protein Synonyms:
    Bcl-2-like Protein 2|Bcl2-L-2|BCL2L2|Bcl-2-Llike Protein 2|Apoptosis Regulator Bcl-W|KIAA0271|BCLW
  • Protein/Peptide Name:
    Bc1-w
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Molecular Weight:
    19.87 kD
  • Sequence:
    Ala2-Thr172
  • Formulation:
    Supplied as a 0.2 um filtered solution of 25mM HEPES, 100mM KCl, 20% Glycerol, pH 7.5. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested Applications:
    Bioassay
  • Cat. No.:
    75788-900
  • Supplier no.:
    91-088

Specifications

About this item

Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

  • Fusion-Tag: C-6 His tag

This recombinant protein can be used for biological assays. For research use only.