Human Recombinant IL-6 (from E. coli)

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses.

ecombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues

Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells.

: For research use only. Not for use in diagnostic or therapeutic procedures.

Conjugation:
Unconjugated
Protein Function:
Cytokines and Growth Factors
Protein/Peptide Type:
Recombinant
Source:
E. coli
Species:
Human
Storage Conditions:
Store at –20 °C prior to reconstitution.
Endotoxin Content:
>0.1 ng/μg
Biological Activity:
Biological Activity tests can vary. Please refer to the Product CoA for information.
Form:
Lyophilized
Gene ID:
3569 P05231
Reconstitution Instructions:
Reconstitution instructions can vary. Please refer to the product CoA for info.
Protease-free:
Y
Protein Synonyms:
HPGF|B-Cell Differentiation Factor (BCDF)|IFN-β2|Interleukin-6|HSF|BSF-2|26 kDa protein|MGI-2
Protein/Peptide Name:
IL-6
Purity:
0.98
Molecular Weight:
20.9 kDa
Sequence:
PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
Endotoxin Level:
Low
Formulation:
Formulation can vary. Please refer to product CoA for information.
Shipping Temperature:
Ambient