About this item
M-CSF is a potent hematopoietic factor produced by a variety of cells, including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival for blood monocytes, tissue macrophages, and their respective progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness and fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. Human M-CSF is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant Human M-CSF is a 36.8 kDa homodimeric protein consisting of two 159 amino acid polypeptide subunits.
- Animal-free
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Specifications
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Storage Conditions:−20 °C
- Endotoxin Content:<0.1 ng/μg of protein (<1 EU/μg).
- Biological Activity:The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
- Animal-Free:Y
- Protein/Peptide Name:MCSF
- Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
- Formulation:Lyophilized
- Shipping Temperature:RT
- Conjugation:Unconjugated
- Protein Function:Cytokines and Growth Factors
- Form:Lyophilized
- Gene ID:1435 P09603
- Reconstitution Instructions:Reconstitution instructions can vary. Please refer to the product CoA for info.
- Protease-free:Y
- Protein Synonyms:MGI-IM|CSF-1|Macrophage Colony Stimulating Factor
- Molecular Weight:36.8 kDa
- Sequence:MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS
- Endotoxin Level:Low