About this item
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues.
- Animal-free
Specifications
- Conjugation:Unconjugated
- Protein Function:Cytokines and Growth Factors
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Mouse
- Storage Conditions:Store at –20 °C prior to reconstitution.
- Endotoxin Content:>0.1 ng/μg
- Biological Activity:Biological Activity tests can vary. Please refer to the Product CoA for information.
- Form:Lyophilized
- Gene ID:16193 P08505
- Reconstitution Instructions:Reconstitution instructions can vary. Please refer to the product CoA for info.
- Protease-free:Y
- Animal-Free:Y
- Protein Synonyms:HPGF|IFN-β2|Interleukin-6|HSF|BSF-2|B-cell Differentiation Factor (BCDF)|26 kDa protein|MGI-2
- Protein/Peptide Name:IL-6
- Purity:0.98
- Molecular Weight:21.7 kDa
- Sequence:MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT
- Endotoxin Level:Low
- Formulation:Formulation can vary. Please refer to product CoA for information.
- Shipping Temperature:Ambient