About this item
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-κB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant Human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues. Manufactured using all Animal-Free reagents.
- Carrier free
- Animal-free
SMCKPITGTI NDLNQQVWTL QGQNLVAVPR SDSVTPVTVA VITCKYPEAL EQGRGDPIYL GIQNPEMCLY CEKVGEQPTL QLKEQKIMDL YGQPEPVKPF LFYRAKTGRT STLESVAFPD WFIASSKRDQ PIILTSELGK SYNTAFELNI ND
Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Specifications
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Storage Conditions:−20 °C
- Endotoxin Content:<0.1 ng/μg of protein (<1 EU/μg).
- Biological Activity:Measured by its ability to induce IL-8 production by human PBMCs.
- Animal-Free:Y
- Protein/Peptide Name:IL36G
- Purity:Greater than 95% by SDS-PAGE gel and HPLC analyses.
- Formulation:Lyophilized
- Shipping Temperature:RT