- Antibody Type:Primary
- Antigen Name:Mitogen-Activated Protein Kinase 10
- Antigen Symbol:MAPK10
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µg
- Cross Adsorption:No
- Form:liquid
- Gene ID:5602
- Antigen Synonyms:MAPK10|JNK3|JNK3A|JNK 46|MGC50974|Mitogen activated protein kinase 10|JNK1A2|MAP kinase p49 3F12|MAPK 8|JNK|MAP kinase 9|MAPK9|JNK 55|JNK2|Mitogen activated protein kinase 9|MAP kinase 8|JNK2BETA|JNK1|p54bSAPK|PRKM10|JNK2B|Mitogen activated protein kinase 8|MAPK8|JNK2ALPHA|JNK21B1/2|MAPK 9
- Storage Buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
- Storage Temperature:Store at –20 °C for 12 months
- Concentration:1 μg/μl
- Shipping Temperature:4°C
- Purification:Purified by Protein A
- Cat. No.:10349-736
- Supplier no.:BS-2997R
MAPK10 (JNK3) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuron-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 (CDK5) can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500; IF(IHC-P): 1:50-200
Type: Primary
Antigen: MAPK10
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat