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Specifications
- Antibody Type:Primary
- Antigen Name:Src Kinase Associated Phosphoprotein 1
- Antigen Symbol:SKAP1
- Clonality:Polyclonal
- Conjugation:FITC (Fluorescein Isothiocyanate)
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat
- Size:100 µL
- Environmentally Preferable:
- Cross Adsorption:No
- Form:liquid
- Antigen Synonyms:SRC family associated phosphoprotein 1|Src kinase-associated phosphoprotein of 55 kDa.|SKAP-55|SRC kinase associated phosphoprotein 55 kD|SKAP 55|SKAP 1|Src kinase associated phosphoprotein of 55 kDa|pp55|Src family-associated phosphoprotein 1|Src kinase-associated phosphoprotein 1|Src kinase associated phosphoprotein 1|SKAP1_HUMAN|SKAP55 adaptor protein|Skap1|SCAP1|SCAP 1
- Storage Buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage Temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping Temperature:4°C
- Purification:Purified by Protein A
- Cat. No.:10304-104
- Supplier no.:BS-13702R-FITC
Specifications
About this item
Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines. SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: SKAP1
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Rat