Specifications
- Antibody Type:Primary
- Antigen Name:Membrane Palmitoylated Protein 5
- Antigen Symbol:MPP5
- Clonality:Polyclonal
- Conjugation:Cy3®
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Size:100 µL
- Cross Adsorption:No
- Form:liquid
- Antigen Synonyms:MAGUK p55 subfamily member 5|PALS 1|Protein associated with Lin-7|Stardust Drosophila|MPP 5|Stardust.|FLJ12615|MPP5|MPP5_HUMAN|PALS1|Membrane protein palmitoylated 5
- Storage Buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage Temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping Temperature:4°C
- Purification:Purified by Protein A
- Cat. No.:10267-342
- Supplier no.:BS-11887R-CY3
Specifications
About this item
Two highly conserved complexes are responsible for the assembly of tight junctions, the Crumbs-Pals1-Patj complex and the Cdc42-Par6-Par3-aPKC complex. Tight junctions assist in the formation of polarity in the epithelia by establishing a barrier to separate apical and basolateral membranes. Pals1, importantly, mediates interaction between the two complexes via interaction with Par6. Loss of Pals1 function results in delayed polarization, decreased transepithelial electrical resistance and an inability to form lumenal cysts. Because tumors exhibit perturbations in epithelial polarity, Pals1 presents a new potential target in the study of carcinogenesis.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: MPP5
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat