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Specifications
- Antibody Type:Primary
- Antigen Name:Complementary Factor I
- Antigen Symbol:CFI
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 350
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Size:100 µL
- Environmentally Preferable:
- Epitope:Heavy Chain
- Cross Adsorption:No
- Form:liquid
- Antigen Synonyms:C3b inactivator|CFI|C3BINA|factor I|Complement Factor I|Konglutinogen activating factor|FactorI|Complement component I|Complement Factor I heavy chain|Factor I heavy chain|OTTHUMP00000219728.|Complement control protein factor I|C3b INA|KAF|I factor|Heavy chain of factor I|F1|C3B/C4B inactivator|CFAI_HUMAN|AHUS3|FI
- Storage Buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage Temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping Temperature:4°C
- Purification:Purified by Protein A
- Cat. No.:10365-396
- Supplier no.:BS-10339R-A350
Specifications
About this item
The complement pathway is an important host defense system that contributes to both innate and acquired immunity. There are three pathways of complement activation: the classical pathway, lectin pathway and alternative pathway. Complement protein Factor I is a key serine protease that modulates the complement cascade by regulating the levels of C3 convertases. It circulates in plasma as a heavily N-glycosylated heterodimer made up of two disulfide linked chains, each carrying three N-linked oligosaccharide chains that may have both structural and functional roles in the interactions with the natural substrate and the cofactor during catalysis. Factor I is a serine protease with a high degree of specificity for C3b and C4b. It requires protein cofactors for cleavage of these complement proteins; Factor H, CR1 or MCP are required for C3b cleavage, and C4bp or CR1 are required for C4b cleavage.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: Factor I heavy chain
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 350
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat