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Specifications
- Antibody Type:Primary
- Antigen Name:Bcl2 modifying Factor
- Antigen Symbol:BMF
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:
- Reactivity:Human
- Western Blot:Yes
- Size:100 µg
- Environmentally Preferable:
- Epitope:C-Terminal
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:90427
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-Bmf antibody was raised with a synthetic peptide corresponding to 14 amino acids near the C-terminus of human Bmf.
- Purification:Anti-Bmf Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Bmf from other sources has not been determined.
- Cat. No.:10800-392
- Supplier no.:600-401-Z77
Specifications
About this item
Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program. Bmf is constitutively expressed in many tissues.
Recommended Dilutions: ELISA: 1:25,000-1:100,000; Immunohistochemsitry: 10 µg/mL; Immunofluorescence Microscopy: 10 µg/mL; Western Blot: 2.5 - 5 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: BMF
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype:
Reactivity: Human