Specifications
- Antibody Type:Primary
- Antigen Name:BCL2-Related Protein A1
- Antigen Symbol:BCL2A1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µg
- Epitope:N-Terminal
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:597
- Antigen Synonyms:Bcl2-L-5|Bcl-2-related protein A1|GRS|BCL2L5|Bcl-2-like protein 5|ACC-1|BFL1|ACC-2|HBPA1|Bfl-1
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-Bfl-1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide from near the N-terminus of human Bfl-1.
- Purification:Anti-Bfl-1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Bfl-1 from other sources has not been determined.
- Cat. No.:10800-346
- Supplier no.:600-401-Z60
Specifications
About this item
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells. At least two isoforms of Bfl-1 are known to exist.
Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 10 µg/mL; Immunofluorescence Microscopy: 20 µg/mL; Western Blot: 1 - 2 µg/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: BCL2A1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat