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Anti-BCL2A1 Rabbit Polyclonal Antibody
Anti-BCL2A1 Rabbit Polyclonal Antibody
Catalog # 10800-346
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Anti-BCL2A1 Rabbit Polyclonal Antibody
Catalog # 10800-346
Supplier Number:  600-401-Z60

Specifications

  • Antibody Type:
    Primary
  • Antigen Name:
    BCL2-Related Protein A1
  • Antigen Symbol:
    BCL2A1
  • Clonality:
    Polyclonal
  • Conjugation:
    Unconjugated
  • ELISA:
    Yes
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Reactivity:
    Human,
    Rat,
    Mouse
  • Western Blot:
    Yes
  • Size:
    100 µg
  • Epitope:
    N-Terminal
  • Format:
    IgG
  • Form:
    Liquid (sterile filtered)
  • Gene ID:
    597
  • Antigen Synonyms:
    Bcl2-L-5|Bcl-2-related protein A1|GRS|BCL2L5|Bcl-2-like protein 5|ACC-1|BFL1|ACC-2|HBPA1|Bfl-1
  • Concentration:
    1 mg/mL by UV absorbance at 280 nm
  • Shipping Temperature:
    Dry Ice
  • Immunogen:
    Anti-Bfl-1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide from near the N-terminus of human Bfl-1.
  • Purification:
    Anti-Bfl-1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Bfl-1 from other sources has not been determined.
  • Cat. No.:
    10800-346
  • Supplier no.:
    600-401-Z60

Specifications

About this item

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells. At least two isoforms of Bfl-1 are known to exist.

Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 10 µg/mL; Immunofluorescence Microscopy: 20 µg/mL; Western Blot: 1 - 2 µg/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: BCL2A1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat