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- Antibody Type:Primary
- Antigen Name:Activating Transcription Factor 6
- Antigen Symbol:ATF6
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoFluorescence:Yes
- Isotype:
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:100 µg
- Environmentally Preferable:
- Epitope:C-Terminal
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:22926
- Antigen Synonyms:ATF6A
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-ATF6 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the C-terminus of human ATF6.
- Purification:Anti-ATF6 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with ATF6 from other sources has not been determined.
- Cat. No.:10800-184
- Supplier no.:600-401-Y72
Disruptions of protein folding and maturation in the endoplasmic reticulum (ER) result in the activation of the unfolded protein response (UPR), an integrated cellular signaling pathway that transmits information from the ER lumen to the cytoplasm and nucleus. Activating transcription factor 6 (ATF6) as well as the ER-transmembrane protein kinases IRE1p and PERK are the major transducers of the UPR. ATF6 is an ER transmembrane protein that is normally bound to the ER chaperone GRP78, but upon ER stress is released from GRP78 and proteolytically cleaved to yield a cytosolic fragment which then migrates to the nucleus, and together with the transcription factor XBP-1, activates transcription of UPR-responsive genes. ATF6 has two isoforms (ATF6a and ATF6b); only ATF6a is recognized by this antibody.
- Recommended Dilutions: ELISA: 1:5000-1:10000; Immunofluorescence Microscopy: 10 μg/mL; Western Blot: 0.5 - 1 µg/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: ATF6
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse