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- Antibody Type:Primary
- Antigen Name:Aryl Hydrocarbon Receptor Interacting Protein-Like 1
- Antigen Symbol:AIPL1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µg
- Environmentally Preferable:
- Epitope:Center
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:23746
- Antigen Synonyms:AIPL2|LCA4
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-Aipl1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 18 amino acid synthetic peptide near the internal region of the human Aipl1.
- Purification:Anti-Aipl1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Aipl1 from other sources has not been determined.
- Cat. No.:10799-626
- Supplier no.:600-401-X93
Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.
Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 2.5 ?g/mL; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 1 - 2 µg/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: AIPL1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Center
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat