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- Antibody Type:Primary
- Antigen Name:Transmembrane Channel-like 6
- Antigen Symbol:TMC6
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:100 µg
- Environmentally Preferable:
- Epitope:Center
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:11322
- Antigen Synonyms:LAK-4P|EVIN1|EVER1|Transmembrane channel-like protein 6|Epidermodysplasia verruciformis protein 1|EV1
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-EVER1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the internal region of human EVER1.
- Purification:Anti-EVER1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.
- Cat. No.:10802-640
- Supplier no.:600-401-BC3
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance.
Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 2.5 ?g/mL; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 1-2 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: TMC6
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Center
Host: Rabbit
Isotype:
Reactivity: Human, Mouse